The Effect of 6 Weeks Swimming and Consumption of Zingiber officinale Roscoe Extract on some Inflammatory and Anti-inflammatory Factors in Heart Tissue of Mice Induced by Breast Cancer

Back ground: Heart disease is one of the side effects of breast cancer. Physical activity and herbs are effective in reducing the inflammatory factors of the heart tissue. Objective: The purpose of this study was to evaluate the effect of 6 weeks of swimming and ginger on some inflammatory factors of the heart tissue of mice induced by breast cancer. Methods: 60 female Balb C-female (6-8 weeks old) and (150-250 g weight) after induction of breast cancer (surgical technique) and familiarity with the environment were randomly divided into 6 groups: healthy control, control Cancer, Cancer-Swim, Cancer-Supplement, Cancer-Saline-Supplement and Cancer-Saline. Swimming and swimming-Supplement groups swam for 6 weeks, five days a week and 60 minutes a day. Supplements and supplements-swimming groups were injected 6 days a day with ginger extract (20 mg / kg) and saline (sodium chloride 0.9%). After intervention, alpha-Tumor necrosis levels (TNFα) and Interleukin10 (IL10) were measured by ELISA and specialized kits. One-way analysis of variance was used to analyze the data (P <0.05). Results: The results showed that induction of cancer was associated with an increase in TNFα and a decrease in IL10. Six weeks of swimming, supplementation and combined intervention reversed these changes. But there is no significant difference between these three independent variables. Conclusion: Swimming, supplementation of ginger and their combination may be effective in modulating inflammatory and anti-inflammatory factors in the heart tissue of breast cancer patients.